Annual Reports & Transparency

At HeartWorks, we believe transparency and accountability are essential to advancing our mission. As a nonprofit organization dedicated to changing outcomes for individuals living with congenital heart disease, we are committed to responsibly investing the resources entrusted to us.

Philanthropic support helps fuel scientific discovery, develop innovative therapies and technologies, and build the infrastructure needed to move promising research closer to patients.

We invite you to explore our financial documents and learn more about how your support helps us build hearts.

2026: A Year of Building What’s Next

In 2026, HeartWorks made significant strides toward its mission of changing outcomes for children and adults living with congenital heart disease (CHD). From expanding our scientific capabilities to advancing patient-specific therapies, this year was about building the people, technology, and infrastructure needed to move innovation closer to patients.

Highlights from 2026 include:

• Organizational Independence: Completed our transition from Mayo Clinic, establishing HeartWorks as a fully independent nonprofit with greater flexibility to accelerate innovation and collaborate with partners across the field.

• Advancing YourHeart: Reached the milestone of 100 patients enrolled for skin biopsies, expanded the manufacturing of patient-specific cardiac cells, and demonstrated the feasibility of delivering these cells through a minimally invasive catheter.

• Expanding Manufacturing: Tripled our initial clinical manufacturing capacity, advanced automation, and increased efficiency to support the production of personalized cell therapies.

• Building Preclinical Capabilities: Established specialized facilities and a dedicated preclinical team in Eau Claire, allowing more research, testing, and development to take place within HeartWorks.

• Innovating Beyond Cell Therapy: Continued advancing the Wanek Circulation technology to support pulmonary blood flow and EctoHeart, our platform for heart preservation, rehabilitation, and preclinical testing.

• Strengthening Patient Connections: Expanded the HeartWorks Co-op, bringing patients and families into the research process through patient-powered data and opportunities to participate in future clinical research.

• Growing Our Impact: Expanded our Eau Claire presence, strengthened partnerships, engaged heart families nationwide, and secured two philanthropic gifts exceeding $1 million each.

Looking Ahead to 2027

The progress made in 2026 laid the groundwork for our next chapter. With expanded capabilities, a growing patient community, and a focused set of priorities, HeartWorks is working to move promising innovations from the laboratory toward clinical application.

Explore our 2027 Priority Tracker to follow the milestones, challenges, and breakthroughs shaping what’s next.